Characterization of PAPP-A Patterns in Chronic Rhinosinusitis

Ennahal A, Wendler O, Pesold V, Müller SK (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Journal of Inflammation Research Dove Medical Press

Book Volume: 19

Article Number: 587722

DOI: 10.2147/JIR.S587722

Abstract

Purpose: High-level expression of pappalysin-A/insulin-like growth factor binding protein/insulin-like growth factor-1 (PAPP-A/IGFBP-4/5/IGF-1 axis) in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) was previously demonstrated by our group. PAPP-A plays a key role in inflammatory diseases and cancer. The aim of this study was to localize PAPP-A in Chronic Rhinosinusitis (CRS), within tissue, inflammatory and different primary cells. Patients and Methods: PAPP-A was localized by immunohistochemistry (IHC) in tissues of CRSwNP (n=41), CRSsNP patients (n=12) as well as in controls (n=12). The data of eosinophil abundance in CRSwNP tissues was obtained from routine pathology. ELISA was used to quantify PAPP-A and ECP non-invasively in CRSwNP mucus (n=67). On a cellular level, PAPP-A was localized by immunofluorescence (IF) in immune and primary cells from CRSwNP (n=18). Results: IHC revealed three distribution patterns of PAPP-A in CRSwNP correlated to the eosinophil abundance. Moreover, IF of different immune cells confirmed the high PAPP-A synthesis by eosinophils, in addition to unspecified subpopulation of T-cells and moderately in mast cells. Besides, a vesicular distribution of PAPP-A in the cytoplasm and the membrane of epithelial and fibroblast cells was shown. Finally, ECP and PAPP-A proved a significant correlation in CRSwNP mucus. Conclusion: Our work is the first to illustrate the three distribution patterns of PAPP-A in CRSwNP. This underlines the potential inflammatory role of PAPP-A, particularly in CRSwNP. Targeting the PAPP-A/IGFBP/IGF-1-axis may be a new therapeutic approach for CRSwNP with high eosinophil abundance.

Authors with CRIS profile

Afaf Ennahal Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Olaf Wendler Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Vanessa Pesold Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Sarina Katrin Ursel Müller-Hübner Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik)

How to cite

APA:

Ennahal, A., Wendler, O., Pesold, V., & Müller, S.K. (2026). Characterization of PAPP-A Patterns in Chronic Rhinosinusitis. Journal of Inflammation Research, 19. https://doi.org/10.2147/JIR.S587722

MLA:

Ennahal, Afaf, et al. "Characterization of PAPP-A Patterns in Chronic Rhinosinusitis." Journal of Inflammation Research 19 (2026).

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