Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes
Kong L, Zong K, Hopfengärtner M, Orzolek BJ, Shenvi R (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Book Volume: 393
Pages Range: 910-911
Journal Issue: 6814
Abstract
traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal catalysts have recently demonstrated competence in cross-coupling transformations through iterative outer-sphere reactions in which product bond formation occurs by serial additions to the ligand, not the metal. Despite the emerging diversity of two-component outer-sphere reactions, comparable multicomponent outer-sphere couplings remain rare. In this study, we describe an iron-catalyzed [1+1+1] synthesis of cyclopropanols through iterative outer-sphere reactions between two carbenes and an ester. this reaction initially generates silyl enol ethers stereo-, regio-, and chemoselectively through a traceless, directed olefination that can be further exploited to enable transformations unavailable to prior methods.
Involved external institutions
United States (USA) (US)How to cite
APA:
Kong, L., Zong, K., Hopfengärtner, M., Orzolek, B.J., & Shenvi, R. (2026). Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes. Science, 393(6814), 910-911. https://doi.org/10.1126/science.aej0194
MLA:
Kong, Lingran, et al. "Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes." Science 393.6814 (2026): 910-911.
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