3D-Printed Alginate Dialdehyde (ADA)–Gelatin (GEL) Hydrogels with Gallic Acid (GA) for Enhanced Multifunctional Properties

Cavalcante CO, Kissel H, Mirt AL, Silva JYR, Alves Júnior S, Boccaccini AR (2026)

Publication Type: Journal article

Publication year: 2026

Journal

ACS Omega American Chemical Society: Open Access Titles / American Chemical Society

Book Volume: 11

Pages Range: 34442-34455

Journal Issue: 23

DOI: 10.1021/acsomega.6c02404

Abstract

This study investigates the incorporation of gallic acid (GA) into alginate dialdehyde–gelatin (ADA–GEL) at GA concentrations (0.125%, 0.25%, and 0.5%). Spectroscopic analyses confirmed GA integration within the matrix, with Raman spectroscopy revealing GA vibrational bands (C–OH and C═C). Thermal and structural assessments indicated preservation of the polymer framework after GA incorporation, while scanning electron microscope (SEM) analysis showed increased surface roughness, suggesting network modification. GA functionalization enhanced phenolic content and antioxidant activity (∼96% DPPH radical scavenging) in films without significantly affecting swelling or degradation behavior, demonstrating maintained structural integrity. At 0.125% and 0.25% GA, improved rheological properties enabled successful three-dimensional (3D) printing of scaffolds with controlled pore size (∼0.6 mm). The printed scaffolds exhibited good cytocompatibility toward MC3T3-E1 preosteoblasts, while the films demonstrated antibacterial activity against Staphylococcus aureus, a pathogen associated with chronic bone infections. Overall, ADA–GEL–GA represents a promising biomaterial for bone tissue regeneration, combining structural stability, printability, and bioactive functionality.

Authors with CRIS profile

Hannah Kissel Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Andreea-Luiza Mirt Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Federal University of Pernambuco / Universidade Federal de Pernambuco BR Brazil (BR)

How to cite

APA:

Cavalcante, C.O., Kissel, H., Mirt, A.-L., Silva, J.Y.R., Alves Júnior, S., & Boccaccini, A.R. (2026). 3D-Printed Alginate Dialdehyde (ADA)–Gelatin (GEL) Hydrogels with Gallic Acid (GA) for Enhanced Multifunctional Properties. ACS Omega, 11(23), 34442-34455. https://doi.org/10.1021/acsomega.6c02404

MLA:

Cavalcante, Caroliny Oliveira, et al. "3D-Printed Alginate Dialdehyde (ADA)–Gelatin (GEL) Hydrogels with Gallic Acid (GA) for Enhanced Multifunctional Properties." ACS Omega 11.23 (2026): 34442-34455.

BibTeX: Download